This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1aqw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1aqw" [edit=sysop:move=sysop])
Current revision (06:32, 7 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1aqw.png|left|200px]]
 
-
<!--
+
==GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE==
-
The line below this paragraph, containing "STRUCTURE_1aqw", creates the "Structure Box" on the page.
+
<StructureSection load='1aqw' size='340' side='right'caption='[[1aqw]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1aqw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQW FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-
{{STRUCTURE_1aqw| PDB=1aqw | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqw OCA], [https://pdbe.org/1aqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqw RCSB], [https://www.ebi.ac.uk/pdbsum/1aqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqw ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqw_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aqw ConSurf].
 +
<div style="clear:both"></div>
-
===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE===
+
==See Also==
-
 
+
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9351803}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 9351803 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_9351803}}
+
-
 
+
-
==About this Structure==
+
-
[[1aqw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQW OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:009351803</ref><references group="xtra"/>
+
-
[[Category: Glutathione transferase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Fahl, W E.]]
+
[[Category: Large Structures]]
-
[[Category: Huber, R.]]
+
[[Category: Fahl WE]]
-
[[Category: Manoharan, T H.]]
+
[[Category: Huber R]]
-
[[Category: Prade, L.]]
+
[[Category: Manoharan TH]]
-
[[Category: Reuter, W.]]
+
[[Category: Prade L]]
-
[[Category: Class pi]]
+
[[Category: Reuter W]]
-
[[Category: Glutathione s-transferase]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transferase-substrate complex]]
+

Current revision

GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE

PDB ID 1aqw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aqw"
Personal tools