1pp5

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[[Image:1pp5.png|left|200px]]
 
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==Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot==
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The line below this paragraph, containing "STRUCTURE_1pp5", creates the "Structure Box" on the page.
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<StructureSection load='1pp5' size='340' side='right'caption='[[1pp5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pp5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PP5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRD_000184:Microcin+J25'>PRD_000184</scene></td></tr>
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{{STRUCTURE_1pp5| PDB=1pp5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pp5 OCA], [https://pdbe.org/1pp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pp5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pp5 ProSAT], [https://www.topsan.org/Proteins/NESGC/1pp5 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MCJA_ECOLX MCJA_ECOLX] Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). May inhibit transcription by binding in RNAP secondary channel and blocking nucleotide substrates access to the catalytic center. Exhibits potent bacteriocidal activity against a range of Enterobacteriaceae, including several pathogenic E.coli, Salmonella and Shigella strains. Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption. Induces bacterial filamentation in susceptible cells in a non-SOS-dependent way, but this phenotype may result from impaired transcription of genes coding for cell division proteins.<ref>PMID:11731133</ref> <ref>PMID:11443089</ref> <ref>PMID:12401787</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle. Here, we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact is a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through the cyclic segment. MccJ25 is the first example of a lariat protoknot involving a backbone-side chain amide linkage.
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===Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot===
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Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot.,Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:14531661<ref>PMID:14531661</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14531661}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1pp5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14531661 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14531661}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1pp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].
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==Reference==
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<ref group="xtra">PMID:014531661</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bayro, M J.]]
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[[Category: Large Structures]]
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[[Category: Ebright, R H.]]
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[[Category: Bayro MJ]]
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[[Category: Huang, J Y.]]
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[[Category: Ebright RH]]
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[[Category: Ma, L C.]]
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[[Category: Huang JY]]
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[[Category: Montelione, G T.]]
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[[Category: Ma L-C]]
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[[Category: Mukhopadhyay, J.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Mukhopadhyay J]]
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[[Category: Swapna, G V.T.]]
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[[Category: Swapna GVT]]
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[[Category: Antibiotic]]
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[[Category: Backbone-sidechain amide linkage]]
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[[Category: Lariat]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Protoknot]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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Current revision

Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot

PDB ID 1pp5

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