This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bqu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1bqu" [edit=sysop:move=sysop])
Current revision (09:33, 21 December 2022) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bqu.png|left|200px]]
 
-
<!--
+
==CYTOKYNE-BINDING REGION OF GP130==
-
The line below this paragraph, containing "STRUCTURE_1bqu", creates the "Structure Box" on the page.
+
<StructureSection load='1bqu' size='340' side='right'caption='[[1bqu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1bqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQU FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqu OCA], [https://pdbe.org/1bqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqu RCSB], [https://www.ebi.ac.uk/pdbsum/1bqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqu ProSAT]</span></td></tr>
-
{{STRUCTURE_1bqu| PDB=1bqu | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bqu_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bqu ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
-
===CYTOKYNE-BINDING REGION OF GP130===
+
Crystal structure of a cytokine-binding region of gp130.,Bravo J, Staunton D, Heath JK, Jones EY EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088<ref>PMID:9501088</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9501088}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1bqu" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 9501088 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_9501088}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[1bqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:009501088</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bravo, J.]]
+
[[Category: Large Structures]]
-
[[Category: Heath, J K.]]
+
[[Category: Bravo J]]
-
[[Category: Jones, E Y.]]
+
[[Category: Heath JK]]
-
[[Category: Staunton, D.]]
+
[[Category: Jones EY]]
-
[[Category: Cytokine receptor]]
+
[[Category: Staunton D]]
-
[[Category: Glycoprotein 130]]
+
-
[[Category: Gp130]]
+
-
[[Category: Interleukine 6 receptor beta subunit]]
+
-
[[Category: Signaling protein]]
+

Current revision

CYTOKYNE-BINDING REGION OF GP130

PDB ID 1bqu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bqu"
Personal tools