3r29

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[[Image:3r29.png|left|200px]]
 
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==Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2==
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The line below this paragraph, containing "STRUCTURE_3r29", creates the "Structure Box" on the page.
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<StructureSection load='3r29' size='340' side='right'caption='[[3r29]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R29 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r29 OCA], [https://pdbe.org/3r29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r29 RCSB], [https://www.ebi.ac.uk/pdbsum/3r29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r29 ProSAT]</span></td></tr>
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{{STRUCTURE_3r29| PDB=3r29 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
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===Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2===
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==See Also==
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*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21613212 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21613212}}
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==About this Structure==
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[[3r29]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R29 OCA].
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==Reference==
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<ref group="xtra">PMID:021613212</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, J.]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Chen J]]
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[[Category: Jiang, H.]]
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[[Category: Chen L]]
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[[Category: Shen, X.]]
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[[Category: Jiang H]]
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[[Category: Zhang, H.]]
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[[Category: Shen X]]
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[[Category: Ligand-binding domain]]
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[[Category: Zhang H]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of RXRalpha ligand-binding domain complexed with corepressor SMRT2

PDB ID 3r29

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OCA

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