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1m63

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[[Image:1m63.png|left|200px]]
 
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==Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes==
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The line below this paragraph, containing "STRUCTURE_1m63", creates the "Structure Box" on the page.
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<StructureSection load='1m63' size='340' side='right'caption='[[1m63]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m63]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M63 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1m63| PDB=1m63 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m63 OCA], [https://pdbe.org/1m63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m63 RCSB], [https://www.ebi.ac.uk/pdbsum/1m63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m63 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes===
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== Function ==
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[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12218175}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12218175 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m63_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12218175}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1m63]] is a 8 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M63 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m63 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin]]
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*[[Calcineurin 3D structures|Calcineurin 3D structures]]
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:012218175</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Huai, Q.]]
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[[Category: Tolypocladium inflatum]]
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[[Category: Ke, H.]]
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[[Category: Huai Q]]
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[[Category: Kim, H Y.]]
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[[Category: Ke H]]
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[[Category: Liu, J O.]]
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[[Category: Kim H-Y]]
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[[Category: Liu, Y.]]
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[[Category: Liu JO]]
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[[Category: Mondragon, A.]]
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[[Category: Liu Y]]
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[[Category: Zhao, Y.]]
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[[Category: Mondragon A]]
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[[Category: Calcineurin]]
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[[Category: Zhao Y]]
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[[Category: Cyclophilin]]
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[[Category: Cyclosporin some]]
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[[Category: Hydrolase-isomerase-immunosuppressant complex]]
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[[Category: Immunophilin]]
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[[Category: Immunosuppressant]]
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Current revision

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

PDB ID 1m63

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