1ih9

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[[Image:1ih9.png|left|200px]]
 
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==NMR Structure of Zervamicin IIB (peptaibol antibiotic) Bound to DPC Micelles==
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The line below this paragraph, containing "STRUCTURE_1ih9", creates the "Structure Box" on the page.
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<StructureSection load='1ih9' size='340' side='right'caption='[[1ih9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ih9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Emericellopsis_salmosynnemata Emericellopsis salmosynnemata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IH9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene></td></tr>
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{{STRUCTURE_1ih9| PDB=1ih9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ih9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih9 OCA], [https://pdbe.org/1ih9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ih9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ih9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ih9 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zervamicin IIB is a 16-amino acid peptaibol that forms voltage-dependent ion channels with multilevel conductance states in planar lipid bilayers and vesicular systems. The spatial structure of zervamicin IIB bound to dodecylphosphocholine micelles was studied by nuclear magnetic resonance spectroscopy. The set of 20 structures obtained has a bent helical conformation with a mean backbone root mean square deviation value of approximately 0.2 A and resembles the structure in isotropic solvents (Balashova et al., 2000. NMR structure of the channel-former zervamicin IIB in isotropic solvents. FEBS Lett 466:333-336). The N-terminus represents an alpha-helix, whereas the C-terminal part has a mixed 3(10)/alpha(R) hydrogen-bond pattern. In the anisotropic micelle environment, the bending angle on Hyp10 (23 degrees) is smaller than that (47 degrees) in isotropic solvents. In the NOESY (Nuclear Overhauser Effect Spectroscopy) spectra, the characteristic attenuation of the peptide signals by 5- and 16-doxylstearate relaxation probes indicates a peripheral mode of the peptaibol binding to the micelle with the N-terminus immersed slightly deeper into micelle interior. Analysis of the surface hydrophobicity reveals that the zervamicin IIB helix is amphiphilic and well suited to formation of a tetrameric transmembrane bundle, according to the barrel-stave mechanism. The results are discussed in a context of voltage-driven peptaibol insertion into membrane.
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===NMR Structure of Zervamicin IIB (peptaibol antibiotic) Bound to DPC Micelles===
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Spatial structure of zervamicin IIB bound to DPC micelles: implications for voltage-gating.,Shenkarev ZO, Balashova TA, Efremov RG, Yakimenko ZA, Ovchinnikova TV, Raap J, Arseniev AS Biophys J. 2002 Feb;82(2):762-71. PMID:11806918<ref>PMID:11806918</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11806918}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ih9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11806918 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11806918}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1ih9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericellopsis_salmosynnemata Emericellopsis salmosynnemata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH9 OCA].
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==Reference==
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<ref group="xtra">PMID:011806918</ref><references group="xtra"/>
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[[Category: Emericellopsis salmosynnemata]]
[[Category: Emericellopsis salmosynnemata]]
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[[Category: Arseniev, A S.]]
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[[Category: Large Structures]]
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[[Category: Balasheva, T A.]]
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[[Category: Arseniev AS]]
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[[Category: Efremov, R G.]]
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[[Category: Balasheva TA]]
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[[Category: Ovchinnikova, T V.]]
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[[Category: Efremov RG]]
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[[Category: Raap, J.]]
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[[Category: Ovchinnikova TV]]
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[[Category: Shenkarev, Z O.]]
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[[Category: Raap J]]
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[[Category: Yakimenko, Z A.]]
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[[Category: Shenkarev ZO]]
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[[Category: Antibiotic]]
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[[Category: Yakimenko ZA]]
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[[Category: Antibiotic bent helix]]
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[[Category: Antifungal]]
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[[Category: Peptaibol antibacterial]]
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[[Category: Zrevamicin]]
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Current revision

NMR Structure of Zervamicin IIB (peptaibol antibiotic) Bound to DPC Micelles

PDB ID 1ih9

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