1amt

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[[Image:1amt.png|left|200px]]
 
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==Crystal structure of alamethicin at 1.5 angstrom resolution==
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The line below this paragraph, containing "STRUCTURE_1amt", creates the "Structure Box" on the page.
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<StructureSection load='1amt' size='340' side='right'caption='[[1amt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1amt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_viride Trichoderma viride]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene></td></tr>
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{{STRUCTURE_1amt| PDB=1amt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1amt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amt OCA], [https://pdbe.org/1amt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1amt RCSB], [https://www.ebi.ac.uk/pdbsum/1amt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1amt ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of alamethicin in nonaqueous solvent has been determined, and refined at 1.5-A resolution. The molecular conformation of the three crystallographically independent molecules is largely alpha-helical with a bend in the helix axis at an internal proline residue. The helix structure is highly amphipathic as most of the solvent-accessible polar atoms lie on a narrow strip of surface parallel to the helix axis. Molecular models for the voltage-gated ion channel, with n-fold symmetry and based on the molecular conformations observed in the crystal, are characterized by strong surface complementarity, a hydrophilic interior and a hydrophobic exterior. The channel structures are stabilized by a hydrated annulus of hydrogen-bonded glutamine residues which produce the greatest restriction in the channel diameter.
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===Crystal structure of alamethicin at 1.5 angstrom resolution===
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A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution.,Fox RO Jr, Richards FM Nature. 1982 Nov 25;300(5890):325-30. PMID:6292726<ref>PMID:6292726</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_6292726}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1amt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 6292726 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_6292726}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1amt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMT OCA].
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[[Category: Trichoderma viride]]
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[[Category: Fox RO]]
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==Reference==
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[[Category: Richards FM]]
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<ref group="xtra">PMID:006292726</ref><references group="xtra"/>
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[[Category: Fox, R O.]]
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[[Category: Richards, F M.]]
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[[Category: Alamethicin]]
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[[Category: Antibacterial]]
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[[Category: Antibiotic]]
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[[Category: Antifungal]]
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[[Category: Peptaibol]]
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Current revision

Crystal structure of alamethicin at 1.5 angstrom resolution

PDB ID 1amt

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