1l1v

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[[Image:1l1v.png|left|200px]]
 
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==UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1l1v", creates the "Structure Box" on the page.
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<StructureSection load='1l1v' size='340' side='right'caption='[[1l1v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
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{{STRUCTURE_1l1v| PDB=1l1v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1v OCA], [https://pdbe.org/1l1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1v RCSB], [https://www.ebi.ac.uk/pdbsum/1l1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1v ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusual interaction mode for the intercalated drug; the central Watson-Crick X/Y base pairs are looped out and displaced by the ActD chromophore. The looped-out bases are not disordered but interact perpendicularly with the base/chromophore and form specific H bonds with DNA. Such a complex structure provides intriguing insights into how ligand interacts with DNA and enlarges the repertoires for sequence-specific DNA recognition.
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===UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE===
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Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.,Chou SH, Chin KH, Chen FM Proc Natl Acad Sci U S A. 2002 May 14;99(10):6625-30. PMID:12011426<ref>PMID:12011426</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12011426}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1l1v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12011426 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12011426}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1l1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1V OCA].
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==Reference==
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<ref group="xtra">PMID:012011426</ref><references group="xtra"/>
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[[Category: Streptomyces antibioticus]]
[[Category: Streptomyces antibioticus]]
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[[Category: Chen, F M.]]
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[[Category: Chen F-M]]
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[[Category: Chin, K H.]]
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[[Category: Chin K-H]]
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[[Category: Chou, S H.]]
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[[Category: Chou S-H]]
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[[Category: Actinomycin]]
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[[Category: Actinomycin d]]
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[[Category: Anti cancer]]
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[[Category: Antibiotic]]
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[[Category: Antitumor]]
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[[Category: Chromophore]]
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[[Category: Depsipeptide]]
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[[Category: Dna-antibiotic complex]]
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[[Category: Mismatch]]
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Current revision

UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE

PDB ID 1l1v

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