2k2s

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[[Image:2k2s.png|left|200px]]
 
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==structure of the MIC1-GLD/MIC6-EGF complex from Toxoplasma gondii==
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The line below this paragraph, containing "STRUCTURE_2k2s", creates the "Structure Box" on the page.
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<StructureSection load='2k2s' size='340' side='right'caption='[[2k2s]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2s OCA], [https://pdbe.org/2k2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2s RCSB], [https://www.ebi.ac.uk/pdbsum/2k2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2s ProSAT]</span></td></tr>
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{{STRUCTURE_2k2s| PDB=2k2s | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIC1_TOXGO MIC1_TOXGO] Adhesin. Required for attachment of the parasite to the host cell prior to invasion. Ensures correct folding of MIC6 and transport of the MIC6-MIC1-MIC4 complex into the micronemes.<ref>PMID:11447133</ref> <ref>PMID:11157983</ref> <ref>PMID:16166092</ref> <ref>PMID:17491595</ref> <ref>PMID:9027753</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The obligate intracellular parasite Toxoplasma gondii, a member of the phylum Apicomplexa that includes Plasmodium spp., is one of the most widespread parasites and the causative agent of toxoplasmosis. Adhesive complexes composed of microneme proteins (MICs) are secreted onto the parasite surface from intracellular stores and fulfil crucial roles in host-cell recognition, attachment and penetration. Here, we report the high-resolution solution structure of a complex between two crucial MICs, TgMIC6 and TgMIC1. Furthermore, we identify two analogous interaction sites within separate epidermal growth factor-like (EGF) domains of TgMIC6-EGF2 and EGF3-and confirm that both interactions are functional for the recognition of host cell receptor in the parasite, using immunofluorescence and invasion assays. The nature of this new mode of recognition of the EGF domain and its abundance in apicomplexan surface proteins suggest a more generalized means of constructing functional assemblies by using EGF domains with highly specific receptor-binding properties.
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===structure of the MIC1-GLD/MIC6-EGF complex from Toxoplasma gondii===
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Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.,Sawmynaden K, Saouros S, Friedrich N, Marchant J, Simpson P, Bleijlevens B, Blackman MJ, Soldati-Favre D, Matthews S EMBO Rep. 2008 Nov;9(11):1149-55. Epub 2008 Sep 26. PMID:18818666<ref>PMID:18818666</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18818666}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2k2s" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18818666 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18818666}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2k2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2S OCA].
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==Reference==
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<ref group="xtra">PMID:018818666</ref><references group="xtra"/>
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[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Matthews, S.]]
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[[Category: Matthews S]]
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[[Category: Cell adhesion]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Egf-like domain]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Microneme protein complex]]
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[[Category: Transmembrane]]
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[[Category: Virulence]]
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Current revision

structure of the MIC1-GLD/MIC6-EGF complex from Toxoplasma gondii

PDB ID 2k2s

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