1bdw

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[[Image:1bdw.png|left|200px]]
 
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==GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)==
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The line below this paragraph, containing "STRUCTURE_1bdw", creates the "Structure Box" on the page.
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<StructureSection load='1bdw' size='340' side='right'caption='[[1bdw]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bdw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BDW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=PRD_000150:GRAMICIDIN+A'>PRD_000150</scene></td></tr>
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{{STRUCTURE_1bdw| PDB=1bdw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdw OCA], [https://pdbe.org/1bdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bdw RCSB], [https://www.ebi.ac.uk/pdbsum/1bdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bdw ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDH) reported here agree with 15N-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDH as the major conformer responsible for ion transport in membranes.
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===GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)===
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The conducting form of gramicidin A is a right-handed double-stranded double helix.,Burkhart BM, Li N, Langs DA, Pangborn WA, Duax WL Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12950-5. PMID:9789021<ref>PMID:9789021</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1bdw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9789021 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9789021}}
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==About this Structure==
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[[1bdw]] is a 2 chain structure of [[Gramicidin]] with sequence from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDW OCA].
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==See Also==
==See Also==
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*[[Gramicidin]]
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*[[Gramicidin|Gramicidin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009789021</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Brevibacillus brevis]]
[[Category: Brevibacillus brevis]]
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[[Category: Burkhart, B M.]]
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[[Category: Large Structures]]
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[[Category: Duax, W L.]]
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[[Category: Burkhart BM]]
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[[Category: Pangborn, W A.]]
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[[Category: Duax WL]]
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[[Category: Antibacterial]]
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[[Category: Pangborn WA]]
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[[Category: Antibiotic]]
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[[Category: Antifungal]]
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[[Category: Double helix]]
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[[Category: Gramicidin]]
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[[Category: Linear gramicidin]]
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[[Category: Membrane ion channel]]
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Current revision

GRAMICIDIN D FROM BACILLUS BREVIS (ACTIVE FORM)

PDB ID 1bdw

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