1fvf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1fvf" [edit=sysop:move=sysop])
Current revision (06:05, 9 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1fvf.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI==
-
The line below this paragraph, containing "STRUCTURE_1fvf", creates the "Structure Box" on the page.
+
<StructureSection load='1fvf' size='340' side='right'caption='[[1fvf]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1fvf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVF FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvf OCA], [https://pdbe.org/1fvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fvf RCSB], [https://www.ebi.ac.uk/pdbsum/1fvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvf ProSAT]</span></td></tr>
-
{{STRUCTURE_1fvf| PDB=1fvf | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O62547_DORPE O62547_DORPE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fvf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fvf ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Sec1 molecules associate with t-SNAREs from the syntaxin family in a heterodimeric complex that plays an essential role in vesicle transport and membrane fusion. Neuronal rat n-Sec1 has an arch-shaped three-domain structure, which binds syntaxin 1a through contacts in domains 1 and 3. In both rat nSec1 and homologous squid s-Sec1, a potential effector-molecule binding-pocket is shaped by residues from domains 1 and 2 and is localized on the opposite side of the syntaxin 1a interaction site. Comparison of several crystal forms of unliganded neuronal squid Sec1 indicates a hinge region between domains 1 and 2 which allows domain 1 to rotate along a central axis. This movement could release syntaxin 1a upon interaction with a yet unspecified Sec1 effector molecule(s). The binding of an effector protein may also directly affect the conformation of the helical hairpin of domain 3, which contributes the other significant syntaxin 1a binding sites in the rat nSec1/syntaxin 1a complex structure but adopts multiple conformations in the unliganded s-Sec1 structures reported here.
-
===CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI===
+
Crystal structures of neuronal squid Sec1 implicate inter-domain hinge movement in the release of t-SNAREs.,Bracher A, Weissenhorn W J Mol Biol. 2001 Feb 9;306(1):7-13. PMID:11178889<ref>PMID:11178889</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11178889}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1fvf" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11178889 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_11178889}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[1fvf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Doryteuthis_pealeii Doryteuthis pealeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVF OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:011178889</ref><references group="xtra"/>
+
[[Category: Doryteuthis pealeii]]
[[Category: Doryteuthis pealeii]]
-
[[Category: Bracher, A.]]
+
[[Category: Large Structures]]
-
[[Category: Weissenhorn, W.]]
+
[[Category: Bracher A]]
-
[[Category: Dimer]]
+
[[Category: Weissenhorn W]]
-
[[Category: Endocytosis-exocytosis complex]]
+
-
[[Category: Helical bundle]]
+
-
[[Category: Left-hand turn connection]]
+
-
[[Category: Parallel beta-sheet]]
+

Current revision

CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI

PDB ID 1fvf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fvf"
Personal tools