3syx

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m (Protected "3syx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 3syx is ON HOLD
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==Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.==
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<StructureSection load='3syx' size='340' side='right'caption='[[3syx]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Vorobiev,S., Su, M., --, --, Seetharaman, J., Sahdev,S., Xiao,R., Ciccosanti,C., Shastry,R., Everett J.K., Nair, R., Acton T.B., Rost, B., Montelione, G.T., Tong,L., Hunt,J.F., Northeast Structural Genomics Consortium (NESG)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3syx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SYX FirstGlance]. <br>
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Description: Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.453&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3syx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3syx OCA], [https://pdbe.org/3syx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3syx RCSB], [https://www.ebi.ac.uk/pdbsum/3syx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3syx ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN] Legius syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SPRE1_HUMAN SPRE1_HUMAN] Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti C]]
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[[Category: Everett JK]]
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[[Category: Hunt JF]]
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[[Category: Montelione GT]]
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[[Category: Nair R]]
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[[Category: Rost B]]
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[[Category: Sahdev S]]
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[[Category: Seetharaman J]]
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[[Category: Shastry R]]
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[[Category: Su M]]
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[[Category: Tong L]]
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[[Category: Vorobiev S]]
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[[Category: Xiao R]]

Current revision

Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.

PDB ID 3syx

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