3qfb

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[[Image:3qfb.jpg|left|200px]]
 
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==Crystal structure of the human thioredoxin reductase-thioredoxin complex==
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The line below this paragraph, containing "STRUCTURE_3qfb", creates the "Structure Box" on the page.
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<StructureSection load='3qfb' size='340' side='right'caption='[[3qfb]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QFB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3qfb| PDB=3qfb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qfb OCA], [https://pdbe.org/3qfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qfb RCSB], [https://www.ebi.ac.uk/pdbsum/3qfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qfb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx). The carboxy-terminal redox centre is found about 20 A apart from the amino-terminal redox centre, with no major conformational changes in TrxR or Trx. Thus, our structure confirms that the enzyme uses a flexible C-terminal arm for electron transport to its substrates, which is stabilized by a guiding bar for controlled transfer. This notion is supported by mutational analyses. Furthermore, essential residues of the interface region were characterized both structurally and functionally. The structure provides templates for future drug design, and contributes to our understanding of redox regulatory processes in mammals.
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===Crystal structure of the human thioredoxin reductase-thioredoxin complex===
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Crystal structure of the human thioredoxin reductase-thioredoxin complex.,Fritz-Wolf K, Kehr S, Stumpf M, Rahlfs S, Becker K Nat Commun. 2011 Jul 12;2:383. doi: 10.1038/ncomms1382. PMID:21750537<ref>PMID:21750537</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qfb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21750537}}, adds the Publication Abstract to the page
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*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21750537 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21750537}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3qfb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QFB OCA].
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==Reference==
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<ref group="xtra">PMID:021750537</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Thioredoxin-disulfide reductase]]
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[[Category: Large Structures]]
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[[Category: Becker, K.]]
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[[Category: Becker K]]
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[[Category: Fritz-Wolf, K.]]
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[[Category: Fritz-Wolf K]]
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[[Category: Kehr, S.]]
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[[Category: Kehr S]]
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[[Category: Rahlfs, S.]]
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[[Category: Rahlfs S]]
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[[Category: Stumpf, M.]]
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[[Category: Stumpf M]]
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[[Category: Electron transport]]
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[[Category: Homodimeric pyridine nucleotide disulfide oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-protein complex]]
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[[Category: Rossmann fold]]
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[[Category: Thioredoxin fold]]
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Current revision

Crystal structure of the human thioredoxin reductase-thioredoxin complex

PDB ID 3qfb

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