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3pqz

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[[Image:3pqz.png|left|200px]]
 
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==Grb7 SH2 with peptide==
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The line below this paragraph, containing "STRUCTURE_3pqz", creates the "Structure Box" on the page.
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<StructureSection load='3pqz' size='340' side='right'caption='[[3pqz]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pqz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PQZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.413&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCS:CARBOXYMETHYLATED+CYSTEINE'>CCS</scene></td></tr>
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{{STRUCTURE_3pqz| PDB=3pqz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pqz OCA], [https://pdbe.org/3pqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pqz RCSB], [https://www.ebi.ac.uk/pdbsum/3pqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pqz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
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===Grb7 SH2 with peptide===
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==See Also==
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*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3pqz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PQZ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Wilce, J A.]]
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[[Category: Large Structures]]
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[[Category: Binds phosphotyrosine]]
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[[Category: Wilce JA]]
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[[Category: Cytoplasmic]]
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[[Category: Protein binding]]
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[[Category: Sh2]]
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[[Category: Tyrosine kinase]]
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Current revision

Grb7 SH2 with peptide

PDB ID 3pqz

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