3sfh

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[[Image:3sfh.png|left|200px]]
 
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==Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor==
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The line below this paragraph, containing "STRUCTURE_3sfh", creates the "Structure Box" on the page.
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<StructureSection load='3sfh' size='340' side='right'caption='[[3sfh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DI:(2R)-2-AMINO-3-(2,4-DICHLOROPHENYL)-1-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPAN-1-ONE'>1DI</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3sfh| PDB=3sfh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfh OCA], [https://pdbe.org/3sfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfh RCSB], [https://www.ebi.ac.uk/pdbsum/3sfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
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===Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor===
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21723733 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21723733}}
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==About this Structure==
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[[3sfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFH OCA].
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==Reference==
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<ref group="xtra">PMID:021723733</ref><references group="xtra"/>
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[[Category: Histone deacetylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Stams, T.]]
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[[Category: Large Structures]]
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[[Category: Vash, B.]]
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[[Category: Stams T]]
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[[Category: Deacetylase]]
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[[Category: Vash B]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor

PDB ID 3sfh

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OCA

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