3skk

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[[Image:3skk.png|left|200px]]
 
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==Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure==
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The line below this paragraph, containing "STRUCTURE_3skk", creates the "Structure Box" on the page.
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<StructureSection load='3skk' size='340' side='right'caption='[[3skk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3skk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SKK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4U7:[(5S)-5-AMINO-5-CARBOXY-6,6-DIFLUOROHEXYL](TRIHYDROXY)BORATE(1-)'>4U7</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_3skk| PDB=3skk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3skk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3skk OCA], [https://pdbe.org/3skk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3skk RCSB], [https://www.ebi.ac.uk/pdbsum/3skk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3skk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
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===Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure===
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==See Also==
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*[[Arginase 3D structures|Arginase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21728378 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21728378}}
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==About this Structure==
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[[3skk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKK OCA].
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==Reference==
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<ref group="xtra">PMID:021728378</ref><references group="xtra"/>
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Christianson, D W.]]
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[[Category: Large Structures]]
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[[Category: Costanzo, L Di.]]
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[[Category: Christianson DW]]
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[[Category: Thorn, K J.]]
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[[Category: Di Costanzo L]]
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[[Category: Abh inhibitor derivative]]
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[[Category: Thorn KJ]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Twinning]]
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Current revision

Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure

PDB ID 3skk

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