3sr2

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[[Image:3sr2.png|left|200px]]
 
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==Crystal Structure of Human XLF-XRCC4 Complex==
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The line below this paragraph, containing "STRUCTURE_3sr2", creates the "Structure Box" on the page.
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<StructureSection load='3sr2' size='340' side='right'caption='[[3sr2]], [[Resolution|resolution]] 3.97&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sr2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SR2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9708&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sr2 OCA], [https://pdbe.org/3sr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sr2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sr2 ProSAT]</span></td></tr>
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{{STRUCTURE_3sr2| PDB=3sr2 | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of Human XLF-XRCC4 Complex===
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[https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3sr2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SR2 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Classen, S.]]
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[[Category: Large Structures]]
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[[Category: Hammel, M.]]
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[[Category: Classen S]]
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[[Category: Tainer, J A.]]
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[[Category: Hammel M]]
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[[Category: Complex]]
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[[Category: Tainer JA]]
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[[Category: Dimerization]]
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[[Category: Dna]]
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[[Category: Dna binding protein-protein binding complex]]
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[[Category: Dna ligase iv]]
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[[Category: Dna ligase]]
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[[Category: Dna repair]]
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[[Category: Dna-binding protein]]
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[[Category: Human]]
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[[Category: Ku]]
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[[Category: Nhej]]
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[[Category: Protein dna-interaction]]
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[[Category: Protein structure]]
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[[Category: Quaternary]]
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[[Category: Xlf]]
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[[Category: Xlf-xrcc4]]
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[[Category: Xrcc4]]
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Current revision

Crystal Structure of Human XLF-XRCC4 Complex

PDB ID 3sr2

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OCA

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