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Beta-2 microglobulin

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(New page: {{STRUCTURE_3mrb| PDB=3mrb | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Human β-2 microglobulin complex with MHC I and HCMV PP65 nonapeptide, 3mrb }} '''Beta-2 microglobulin''' (...)
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{{STRUCTURE_3mrb| PDB=3mrb | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Human β-2 microglobulin complex with MHC I and HCMV PP65 nonapeptide, [[3mrb]] }}
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<StructureSection load='' size='350' side='right' scene='45/459284/Cv/1' caption='Human β-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), [[3mrb]]'>
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[[Beta-2 microglobulin]] ('''B2M''') is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. <ref>PMID:21131979</ref> For more details, see: [[Human beta two microglobulin]] and [[Molecular playground/beta 2 microglobulin]].
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<br/>
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[[Image:MHC Class 1.png|thumb|200px|left|Diagram of MHC I Complex]]
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{{Clear}}
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== Disease ==
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'''Beta-2 microglobulin''' (B2M) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess.
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Elevated B2M levels are found in patients of liver cirrhosis<ref>PMID:3884477</ref> and hepatitis<ref>PMID:29221492</ref>. Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients. It is caused by B2M fibrils amyloid deposits<ref>PMID:10737162</ref>.
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== Relevance ==
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B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma.
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== Structural Highlights ==
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<scene name='45/459284/Cv/2'>Human β-2 microglobulin with MHC class I HLA-A2 and HCMV PP65 nonapeptide</scene> ([[3mrb]]).
== 3D Structures of β-2 microglobulin ==
== 3D Structures of β-2 microglobulin ==
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[[Beta-2 microglobulin 3D structures]]
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</StructureSection>
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== References ==
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<references/>
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human β-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), 3mrb

Drag the structure with the mouse to rotate

References

  1. ↑ Liu C, Sawaya MR, Eisenberg D. beta-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol. 2011 Jan;18(1):49-55. Epub 2010 Dec 5. PMID:21131979 doi:10.1038/nsmb.1948
  2. ↑ Nyberg A, Loof L, Hallgren R. Serum beta 2-microglobulin levels in primary biliary cirrhosis. Hepatology. 1985 Mar-Apr;5(2):282-5. doi: 10.1002/hep.1840050222. PMID:3884477 doi:http://dx.doi.org/10.1002/hep.1840050222
  3. ↑ Okoror LE, Ajayi AO, Ijalana OB. Elevated serum beta2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria. BMC Res Notes. 2017 Dec 8;10(1):719. doi: 10.1186/s13104-017-3015-9. PMID:29221492 doi:http://dx.doi.org/10.1186/s13104-017-3015-9
  4. ↑ Drueke TB. Beta2-microglobulin and amyloidosis. Nephrol Dial Transplant. 2000;15 Suppl 1:17-24. doi:, 10.1093/oxfordjournals.ndt.a027958. PMID:10737162 doi:http://dx.doi.org/10.1093/oxfordjournals.ndt.a027958

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