2l2r

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[[Image:2l2r.png|left|200px]]
 
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==Helical hairpin structure of a novel antimicrobial peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli)==
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The line below this paragraph, containing "STRUCTURE_2l2r", creates the "Structure Box" on the page.
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<StructureSection load='2l2r' size='340' side='right'caption='[[2l2r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echinochloa_crus-galli Echinochloa crus-galli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2r OCA], [https://pdbe.org/2l2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2r RCSB], [https://www.ebi.ac.uk/pdbsum/2l2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2r ProSAT]</span></td></tr>
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{{STRUCTURE_2l2r| PDB=2l2r | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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This study presents purification, activity characterization, and (1)H NMR study of the novel antifungal peptide EcAMP1 from kernels of barnyard grass Echinochloa crus-galli. The peptide adopts a disulfide-stabilized alpha-helical hairpin structure in aqueous solution and thus represents a novel fold among naturally occurring antimicrobial peptides. Micromolar concentrations of EcAMP1 were shown to inhibit growth of several fungal phytopathogens. Confocal microscopy revealed intensive EcAMP1 binding to the surface of fungal conidia followed by internalization and accumulation in the cytoplasm without disturbance of membrane integrity. Close spatial structure similarity between EcAMP1, the trypsin inhibitor VhTI from seeds of Veronica hederifolia, and some scorpion and cone snail toxins suggests natural elaboration of different functions on a common fold.
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===Helical hairpin structure of a novel antimicrobial peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli)===
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Disulfide-stabilized Helical Hairpin Structure and Activity of a Novel Antifungal Peptide EcAMP1 from Seeds of Barnyard Grass (Echinochloa crus-galli).,Nolde SB, Vassilevski AA, Rogozhin EA, Barinov NA, Balashova TA, Samsonova OV, Baranov YV, Feofanov AV, Egorov TA, Arseniev AS, Grishin EV J Biol Chem. 2011 Jul 15;286(28):25145-53. Epub 2011 May 11. PMID:21561864<ref>PMID:21561864</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2l2r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21561864 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21561864}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2l2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echinochloa_crus-galli Echinochloa crus-galli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2R OCA].
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==Reference==
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<ref group="xtra">PMID:021561864</ref><references group="xtra"/>
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[[Category: Echinochloa crus-galli]]
[[Category: Echinochloa crus-galli]]
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[[Category: Arseniev, A S.]]
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[[Category: Large Structures]]
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[[Category: Balashova, T A.]]
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[[Category: Arseniev AS]]
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[[Category: Barinov, N A.]]
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[[Category: Balashova TA]]
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[[Category: Egorov, T A.]]
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[[Category: Barinov NA]]
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[[Category: Grishin, E V.]]
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[[Category: Egorov TA]]
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[[Category: Nolde, S B.]]
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[[Category: Grishin EV]]
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[[Category: Rogozhin, E A.]]
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[[Category: Nolde SB]]
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[[Category: Vassilevski, A A.]]
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[[Category: Rogozhin EA]]
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[[Category: Antifungal peptide]]
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[[Category: Vassilevski AA]]
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[[Category: Antimicrobial peptide]]
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[[Category: Antimicrobial protein]]
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[[Category: Disulfide-stabilized helical hairpin]]
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Current revision

Helical hairpin structure of a novel antimicrobial peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli)

PDB ID 2l2r

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