1e68

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[[Image:1e68.png|left|200px]]
 
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==Solution structure of bacteriocin AS-48==
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The line below this paragraph, containing "STRUCTURE_1e68", creates the "Structure Box" on the page.
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<StructureSection load='1e68' size='340' side='right'caption='[[1e68]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1e68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E68 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e68 OCA], [https://pdbe.org/1e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e68 RCSB], [https://www.ebi.ac.uk/pdbsum/1e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e68 ProSAT]</span></td></tr>
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{{STRUCTURE_1e68| PDB=1e68 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q47765_ENTFL Q47765_ENTFL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of bacteriocin AS-48, a 70-residue cyclic polypeptide from Enterococcus faecalis, consists of a globular arrangement of five alpha-helices enclosing a compact hydrophobic core. The head-to-tail union lies in the middle of helix 5, a fact that is shown to have a pronounced effect on the stability of the three-dimensional structure. Positive charges in the side chains of residues in helix 4 and in the turn linking helix 4 to helix 5 form a cluster that most probably determine its antibacterial activity by promoting pore formation in cell membranes. A similar five-helix structural motif has been found in the antimicrobial NK-lysin, an effector polypeptide of T and natural killer (NK) cells. Bacteriocin AS-48 lacks the three disulfide bridges characteristic of the saposin fold present in NK-lysin, and has no sequence homology with it. Nevertheless, the similar molecular architecture and high positive charge strongly suggest a common mechanism of antibacterial action.
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===SOLUTION STRUCTURE OF BACTERIOCIN AS-48===
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Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin.,Gonzalez C, Langdon GM, Bruix M, Galvez A, Valdivia E, Maqueda M, Rico M Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11221-6. PMID:11005847<ref>PMID:11005847</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11005847}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1e68" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11005847 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11005847}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1e68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E68 OCA].
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==Reference==
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<ref group="xtra">PMID:011005847</ref><ref group="xtra">PMID:009729795</ref><references group="xtra"/>
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Bruix, M.]]
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[[Category: Large Structures]]
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[[Category: Galvez, A.]]
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[[Category: Bruix M]]
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[[Category: Gonzalez, C.]]
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[[Category: Galvez A]]
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[[Category: Langdon, G.]]
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[[Category: Gonzalez C]]
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[[Category: Maqueda, M.]]
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[[Category: Langdon G]]
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[[Category: Rico, M.]]
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[[Category: Maqueda M]]
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[[Category: Valdivia, E.]]
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[[Category: Rico M]]
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[[Category: Antibiotic]]
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[[Category: Valdivia E]]
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[[Category: Bacteriocin]]
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[[Category: Cationic antibacterial peptide]]
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[[Category: Cyclic polypeptide]]
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[[Category: Five-helix globule]]
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Current revision

Solution structure of bacteriocin AS-48

PDB ID 1e68

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