3sto
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Serpin from the trematode Schistosoma Haematobium== | |
| + | <StructureSection load='3sto' size='340' side='right'caption='[[3sto]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3STO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sto OCA], [https://pdbe.org/3sto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sto RCSB], [https://www.ebi.ac.uk/pdbsum/3sto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sto ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q26502_SCHHA Q26502_SCHHA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Parasitic organisms are constantly challenged by the defence mechanisms of their respective hosts, which often depend on serine protease activities. Consequently, protease inhibitors such as those belonging to the serpin superfamily have emerged as protective elements that support the survival of the parasites. This report describes the crystal structure of ShSPI, a serpin from the trematode Schistosoma haematobium. The protein is exposed on the surface of invading cercaria as well as of adult worms, suggesting its involvement in the parasite-host interaction. While generally conforming to the well established serpin fold, the structure reveals several distinctive features, mostly concerning the helical subdomain of the protein. It is proposed that these peculiarities are related to the unique biological properties of a small serpin subfamily which is conserved among pathogenic schistosomes. | ||
| - | + | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.,Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergraber OH Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):686-94. doi:, 10.1107/S0907444912008372. Epub 2012 May 17. PMID:22683791<ref>PMID:22683791</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3sto" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schistosoma haematobium]] | ||
| + | [[Category: Blanton RE]] | ||
| + | [[Category: Granzin J]] | ||
| + | [[Category: Lee X]] | ||
| + | [[Category: Weiergraeber OH]] | ||
Current revision
Serpin from the trematode Schistosoma Haematobium
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