3t3a
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3t3a is ON HOLD Authors: Kolenko, P., Rozbesky, D., Bezouska, K., Hasek, J., Dohnalek, J. Description: Crystal structure of H107R mutant of extrace...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A== | |
| + | <StructureSection load='3t3a' size='340' side='right'caption='[[3t3a]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3t3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T3A FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t3a OCA], [https://pdbe.org/3t3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t3a RCSB], [https://www.ebi.ac.uk/pdbsum/3t3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t3a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KLRBA_MOUSE KLRBA_MOUSE] Plays a stimulatory role on natural killer (NK) cell cytotoxicity.<ref>PMID:16751398</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal. Unlike the structure of the wild-type receptor in space group I4(1)22 with a single chain per asymmetric unit, the crystals of the variant belonged to space group I4(1) with a dimer in the asymmetric unit. Different degrees of merohedral twinning were detected in five data sets collected from different crystals. The mutation does not have a significant impact on the overall structure, but led to the binding of an additional phosphate ion at the interface of the molecules. | ||
| - | + | Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 A resolution.,Kolenko P, Rozbesky D, Vanek O, Bezouska K, Hasek J, Dohnalek J Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1519-23., Epub 2011 Nov 30. PMID:22139156<ref>PMID:22139156</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3t3a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Bezouska K]] | ||
| + | [[Category: Dohnalek J]] | ||
| + | [[Category: Hasek J]] | ||
| + | [[Category: Kolenko P]] | ||
| + | [[Category: Rozbesky D]] | ||
Current revision
Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A
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