3t5i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3t5i is ON HOLD Authors: Ismail, S.A, Yong-Xiang, C, Wittinghofer, A Description: Structure of Fully modified farnesylated Rheb Peptide in complex ...) |
|||
| (12 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D== | |
| + | <StructureSection load='3t5i' size='340' side='right'caption='[[3t5i]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3t5i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=FAR:FARNESYL'>FAR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5i OCA], [https://pdbe.org/3t5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5i RCSB], [https://www.ebi.ac.uk/pdbsum/3t5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen Y-X]] | ||
| + | [[Category: Ismail SA]] | ||
| + | [[Category: Wittinghofer A]] | ||
Current revision
Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D
| |||||||||||
