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3q3t

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[[Image:3q3t.jpg|left|200px]]
 
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==Alkyl Amine Renin Inhibitors: Filling S1 from S3==
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The line below this paragraph, containing "STRUCTURE_3q3t", creates the "Structure Box" on the page.
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<StructureSection load='3q3t' size='340' side='right'caption='[[3q3t]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q3t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RX0:[(1S,3R,4S)-3-AMINO-4-HYDROXYCYCLOPENTYL]{(3R)-3-[(1S)-1-(BIPHENYL-2-YL)-1-HYDROXY-5-METHOXYPENTYL]PIPERIDIN-1-YL}METHANONE'>RX0</scene></td></tr>
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{{STRUCTURE_3q3t| PDB=3q3t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3t OCA], [https://pdbe.org/3q3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3t RCSB], [https://www.ebi.ac.uk/pdbsum/3q3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3t ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN] Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:[https://omim.org/entry/267430 267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).<ref>PMID:16116425</ref> Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:[https://omim.org/entry/613092 613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.<ref>PMID:19664745</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RENI_HUMAN RENI_HUMAN] Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
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===Alkyl Amine Renin Inhibitors: Filling S1 from S3===
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==See Also==
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*[[Renin|Renin]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21741239 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21741239}}
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==About this Structure==
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[[3q3t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3T OCA].
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==Reference==
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<ref group="xtra">PMID:021741239</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Renin]]
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[[Category: Large Structures]]
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[[Category: McKeever, B.]]
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[[Category: McKeever B]]
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[[Category: Wu, Z.]]
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[[Category: Wu Z]]
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[[Category: Aspartate protease]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hypertension]]
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[[Category: Renin inhibitor]]
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[[Category: Zymogen]]
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Current revision

Alkyl Amine Renin Inhibitors: Filling S1 from S3

PDB ID 3q3t

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