3axl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:52, 9 October 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3axl.jpg|left|200px]]
 
-
<!--
+
==Murine Valpha 10 Vbeta 8.1 T-cell receptor==
-
The line below this paragraph, containing "STRUCTURE_3axl", creates the "Structure Box" on the page.
+
<StructureSection load='3axl' size='340' side='right'caption='[[3axl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3axl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AXL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3axl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3axl OCA], [https://pdbe.org/3axl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3axl RCSB], [https://www.ebi.ac.uk/pdbsum/3axl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3axl ProSAT]</span></td></tr>
-
{{STRUCTURE_3axl| PDB=3axl | SCENE= }}
+
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(alpha)14-J(alpha)18) T cell antigen receptor (TCR) alpha-chain and recognition of the glycolipid alpha-galactosylceramide (alpha-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of alpha-GalCer-reactive NKT cells that expressed a canonical V(alpha)10-J(alpha)50 TCR alpha-chain, which showed a preference for alpha-glucosylceramide (alpha-GlcCer) and bacterial alpha-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCRalpha sequence identity, the V(alpha)10 TCR-CD1d-alpha-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-alpha-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
-
===Murine Valpha 10 Vbeta 8.1 T-cell receptor===
+
A semi-invariant V(alpha)10(+) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.,Uldrich AP, Patel O, Cameron G, Pellicci DG, Day EB, Sullivan LC, Kyparissoudis K, Kjer-Nielsen L, Vivian JP, Cao B, Brooks AG, Williams SJ, Illarionov P, Besra GS, Turner SJ, Porcelli SA, McCluskey J, Smyth MJ, Rossjohn J, Godfrey DI Nat Immunol. 2011 Jun 12;12(7):616-23. doi: 10.1038/ni.2051. PMID:21666690<ref>PMID:21666690</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3axl" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_21666690}}, adds the Publication Abstract to the page
+
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21666690 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21666690}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3axl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXL OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021666690</ref><references group="xtra"/>
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Patel, O.]]
+
[[Category: Patel O]]
-
[[Category: Rossjohn, J.]]
+
[[Category: Rossjohn J]]
-
[[Category: Cd1d binding]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunoglobulin fold]]
+
-
[[Category: T-cell receptor]]
+

Current revision

Murine Valpha 10 Vbeta 8.1 T-cell receptor

PDB ID 3axl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3axl"
Personal tools