2y8r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:10, 23 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2y8r.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of apo AMA1 mutant (Tyr230Ala) from Toxoplasma gondii==
-
The line below this paragraph, containing "STRUCTURE_2y8r", creates the "Structure Box" on the page.
+
<StructureSection load='2y8r' size='340' side='right'caption='[[2y8r]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2y8r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8R FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_2y8r| PDB=2y8r | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8r OCA], [https://pdbe.org/2y8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8r RCSB], [https://www.ebi.ac.uk/pdbsum/2y8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8r ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AMA1_TOXGV AMA1_TOXGV] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the parasite-host cell interface. MJ assembly is initiated by injection of parasite rhoptry neck proteins (RONs) into the host cell, where RON2 spans the membrane and functions as a receptor for apical membrane antigen 1 (AMA1) on the parasite. We have determined the structure of TgAMA1 complexed with a RON2 peptide at 1.95 angstrom resolution. A stepwise assembly mechanism results in an extensive buried surface area, enabling the MJ complex to resist the mechanical forces encountered during host cell invasion. Besides providing insights into host cell invasion by apicomplexan parasites, the structure offers a basis for designing therapeutics targeting these global pathogens.
-
===CRYSTAL STRUCTURE OF APO AMA1 MUTANT (TYR230ALA) FROM TOXOPLASMA GONDII===
+
Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21778402}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2y8r" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 21778402 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21778402}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[2y8r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8R OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021778402</ref><references group="xtra"/>
+
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
-
[[Category: Boulanger, M J.]]
+
[[Category: Boulanger MJ]]
-
[[Category: Crawford, J.]]
+
[[Category: Crawford J]]
-
[[Category: Douguet, D.]]
+
[[Category: Douguet D]]
-
[[Category: Lamarque, M H.]]
+
[[Category: Lamarque MH]]
-
[[Category: Lebrun, M.]]
+
[[Category: Lebrun M]]
-
[[Category: Pugniere, M.]]
+
[[Category: Pugniere M]]
-
[[Category: Roques, M.]]
+
[[Category: Roques M]]
-
[[Category: Tonkin, M L.]]
+
[[Category: Tonkin ML]]
-
[[Category: Invasion]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Moving junction]]
+

Current revision

Crystal structure of apo AMA1 mutant (Tyr230Ala) from Toxoplasma gondii

PDB ID 2y8r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2y8r"
Personal tools