1aw8

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[[Image:1aw8.png|left|200px]]
 
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==PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE==
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The line below this paragraph, containing "STRUCTURE_1aw8", creates the "Structure Box" on the page.
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<StructureSection load='1aw8' size='340' side='right'caption='[[1aw8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1aw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AW8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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{{STRUCTURE_1aw8| PDB=1aw8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aw8 OCA], [https://pdbe.org/1aw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aw8 RCSB], [https://www.ebi.ac.uk/pdbsum/1aw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aw8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAND_ECOLI PAND_ECOLI] Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.<ref>PMID:6767707</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/1aw8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aw8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of L-aspartate-alpha-decarboxylase from E. coli has been determined at 2.2 A resolution. The enzyme is a tetramer with pseudofour-fold rotational symmetry. The subunits are six-stranded beta-barrels capped by small alpha-helices at each end. The active sites are located between adjacent subunits. The electron density provides evidence for catalytic pyruvoyl groups at three active sites and an ester at the fourth. The ester is an intermediate in the autocatalytic self-processing leading to formation of the pyruvoyl group. This unprecedented structure provides novel insights into the general phenomenon of protein processing.
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===PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE===
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Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.,Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C Nat Struct Biol. 1998 Apr;5(4):289-93. PMID:9546220<ref>PMID:9546220</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1aw8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9546220}}, adds the Publication Abstract to the page
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*[[Aspartate decarboxylase 3D structures|Aspartate decarboxylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9546220 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9546220}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1aw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AW8 OCA].
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==Reference==
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<ref group="xtra">PMID:009546220</ref><references group="xtra"/>
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[[Category: Aspartate 1-decarboxylase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Abell, C.]]
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[[Category: Large Structures]]
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[[Category: Albert, A.]]
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[[Category: Abell C]]
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[[Category: Blundell, T L.]]
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[[Category: Albert A]]
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[[Category: Dhanaraj, V.]]
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[[Category: Blundell TL]]
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[[Category: Genschel, U.]]
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[[Category: Dhanaraj V]]
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[[Category: Khan, G.]]
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[[Category: Genschel U]]
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[[Category: Pulido, R.]]
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[[Category: Khan G]]
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[[Category: Ramjee, M K.]]
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[[Category: Pulido R]]
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[[Category: Smith, A G.]]
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[[Category: Ramjee MK]]
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[[Category: Sybanda, B L.]]
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[[Category: Smith AG]]
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[[Category: Vondelf, F.]]
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[[Category: Sybanda BL]]
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[[Category: Witty, M.]]
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[[Category: Witty M]]
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[[Category: Decarboxylase]]
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[[Category: Von Delf F]]
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[[Category: Lyase]]
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[[Category: Pantothenate pathway]]
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[[Category: Protein self-processing]]
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Current revision

PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE

PDB ID 1aw8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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