3nrq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:33, 28 December 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3nrq.png|left|200px]]
 
-
<!--
+
==Crystal structure of copper-reconstituted FetP from uropathogenic Escherichia coli strain F11==
-
The line below this paragraph, containing "STRUCTURE_3nrq", creates the "Structure Box" on the page.
+
<StructureSection load='3nrq' size='340' side='right'caption='[[3nrq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3nrq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_F11 Escherichia coli F11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NRQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-
{{STRUCTURE_3nrq| PDB=3nrq | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nrq OCA], [https://pdbe.org/3nrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nrq RCSB], [https://www.ebi.ac.uk/pdbsum/3nrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nrq ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In the uropathogenic Escherichia coli strain F11, in silico genome analysis revealed the dicistronic iron uptake operon fetMP, which is under iron-regulated control mediated by the Fur regulator. The expression of fetMP in a mutant strain lacking known iron uptake systems improved growth under iron depletion and increased cellular iron accumulation. FetM is a member of the iron/lead transporter superfamily and is essential for iron uptake by the Fet system. FetP is a periplasmic protein that enhanced iron uptake by FetM. Recombinant FetP bound Cu(II) and the iron analog Mn(II) at distinct sites. The crystal structure of the FetP dimer reveals a copper site in each FetP subunit that adopts two conformations: CuA with a tetrahedral geometry composed of His(44), Met(90), His(97), and His(127), and CuB, a second degenerate octahedral geometry with the addition of Glu(46). The copper ions of each site occupy distinct positions and are separated by approximately 1.3 A. Nearby, a putative additional Cu(I) binding site is proposed as an electron source that may function with CuA/CuB displacement to reduce Fe(III) for transport by FetM. Together, these data indicate that FetMP is an additional iron uptake system composed of a putative iron permease and an iron-scavenging and potentially iron-reducing periplasmic protein.
-
===Crystal structure of copper-reconstituted FetP from uropathogenic Escherichia coli strain F11===
+
Characterization of a Dipartite Iron Uptake System from Uropathogenic Escherichia coli Strain F11.,Koch D, Chan AC, Murphy ME, Lilie H, Grass G, Nies DH J Biol Chem. 2011 Jul 15;286(28):25317-30. Epub 2011 May 19. PMID:21596746<ref>PMID:21596746</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21596746}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3nrq" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 21596746 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21596746}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Escherichia coli F11]]
-
[[3nrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NRQ OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Chan ACK]]
-
==Reference==
+
[[Category: Murphy MEP]]
-
<ref group="xtra">PMID:021596746</ref><references group="xtra"/>
+
-
[[Category: Escherichia coli]]
+
-
[[Category: Chan, A C.K.]]
+
-
[[Category: Murphy, M E.P.]]
+
-
[[Category: Copper binding]]
+
-
[[Category: Immunoglobulin-like fold]]
+
-
[[Category: Iron transporter]]
+
-
[[Category: Transport protein]]
+

Current revision

Crystal structure of copper-reconstituted FetP from uropathogenic Escherichia coli strain F11

PDB ID 3nrq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nrq"
Personal tools