2vz6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2vz6" [edit=sysop:move=sysop])
Current revision (15:38, 13 December 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2vz6.png|left|200px]]
 
-
<!--
+
==Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804==
-
The line below this paragraph, containing "STRUCTURE_2vz6", creates the "Structure Box" on the page.
+
<StructureSection load='2vz6' size='340' side='right'caption='[[2vz6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2vz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZ6 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEF:(2Z,3E)-2,3-BIINDOLE-2,3(1H,1H)-DIONE+3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}'>FEF</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
-
{{STRUCTURE_2vz6| PDB=2vz6 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vz6 OCA], [https://pdbe.org/2vz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vz6 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/2vz6_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vz6 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Long-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII). CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Here we describe the crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, structures of all four human CaMKII catalytic domains in their autoinhibited states, as well as structures of human CaMKII oligomerization domains in their tetradecameric and physiological dodecameric states. All four autoinhibited human CaMKIIs were monomeric in the determined crystal structures but associated weakly in solution. In the CaMKIIdelta/Ca2+/CaM complex, the inhibitory region adopted an extended conformation and interacted with an adjacent catalytic domain positioning T287 into the active site of the interacting protomer. Comparisons with autoinhibited CaMKII structures showed that binding of calmodulin leads to the rearrangement of residues in the active site to a conformation suitable for ATP binding and to the closure of the binding groove for the autoinhibitory helix by helix alphaD. The structural data, together with biophysical interaction studies, reveals the mechanism of CaMKII activation by calmodulin and explains many of the unique regulatory properties of these two essential signaling molecules. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3-D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1.
-
===STRUCTURE OF HUMAN CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA (CAMK2A) IN COMPLEX WITH INDIRUBIN E804===
+
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.,Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654<ref>PMID:20668654</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2vz6" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20668654}}, adds the Publication Abstract to the page
+
*[[Calcium/Calmodulin-dependent protein kinase|Calcium/Calmodulin-dependent protein kinase]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20668654 is the PubMed ID number.
+
*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_20668654}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[2vz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZ6 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:020668654</ref><references group="xtra"/>
+
-
[[Category: Calcium/calmodulin-dependent protein kinase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess-Brown, N.]]
+
[[Category: Bountra C]]
-
[[Category: Delft, F Von.]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Fedorov, O.]]
+
[[Category: Fedorov O]]
-
[[Category: King, O.]]
+
[[Category: King O]]
-
[[Category: Knapp, S.]]
+
[[Category: Knapp S]]
-
[[Category: Murray, J W.]]
+
[[Category: Murray JW]]
-
[[Category: Parizotto, E.]]
+
[[Category: Parizotto E]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Pike ACW]]
-
[[Category: Rellos, P.]]
+
[[Category: Rellos P]]
-
[[Category: Roos, A.]]
+
[[Category: Roos A]]
-
[[Category: Salah, E.]]
+
[[Category: Salah E]]
-
[[Category: Shrestha, L.]]
+
[[Category: Shrestha L]]
-
[[Category: Wikstroem, M.]]
+
[[Category: Wikstroem M]]
-
[[Category: Atp-binding]]
+
[[Category: Von Delft F]]
-
[[Category: Brain]]
+
-
[[Category: Calmodulin-binding]]
+
-
[[Category: Cell junction]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Kinase]]
+
-
[[Category: Long term potentiation]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nmda receptor signalling]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Serine/threonine-protein kinase]]
+
-
[[Category: Synapse]]
+
-
[[Category: Transferase]]
+

Current revision

Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex with Indirubin E804

PDB ID 2vz6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vz6"
Personal tools