3p0e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine== | |
| + | <StructureSection load='3p0e' size='340' side='right'caption='[[3p0e]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p0e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAU:1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE'>BAU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0e OCA], [https://pdbe.org/3p0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0e RCSB], [https://www.ebi.ac.uk/pdbsum/3p0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UPP2_HUMAN UPP2_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates. | ||
| - | + | ==See Also== | |
| - | + | *[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Castronovo S]] | ||
| + | [[Category: Roosild TP]] | ||
| + | [[Category: Villoso A]] | ||
Current revision
Structure of hUPP2 in an active conformation with bound 5-benzylacyclouridine
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