3snl

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'''Unreleased structure'''
 
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The entry 3snl is ON HOLD until Paper Publication
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==Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors==
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<StructureSection load='3snl' size='340' side='right'caption='[[3snl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3snl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SNL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=548:6-CHLORO-3,4-DIMETHYL-1-(3-METHYLPYRIDIN-4-YL)-8-(TRIFLUOROMETHYL)IMIDAZO[1,5-A]QUINOXALINE'>548</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3snl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snl OCA], [https://pdbe.org/3snl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3snl RCSB], [https://www.ebi.ac.uk/pdbsum/3snl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3snl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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Authors: Malamas, M.S., Ni, Y., Erdei, J., Stange, H., Schindler, R., Lankau, H.-J., Grunwald, C, Fan, K.Y., Parris, K.D., Langen, B., Egerland, U., Hage, T., Marquis, K.L., Grauer, S, Brennan, J., Navarra, R., Graf, R., Harrison, B.L., Robichaud, A., Kronbach, T., Pangalos, M., Hofgen, N., Brandon, N.J.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brandon NJ]]
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[[Category: Brennan J]]
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[[Category: Egerland U]]
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[[Category: Erdei J]]
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[[Category: Fan KY]]
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[[Category: Graf R]]
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[[Category: Grauer S]]
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[[Category: Grunwald C]]
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[[Category: Hage T]]
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[[Category: Harrison BL]]
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[[Category: Hofgen N]]
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[[Category: Kronbach T]]
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[[Category: Langen B]]
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[[Category: Lankau H-J]]
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[[Category: Malamas MS]]
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[[Category: Marquis KL]]
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[[Category: Navarra R]]
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[[Category: Ni Y]]
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[[Category: Pangalos M]]
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[[Category: Parris KD]]
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[[Category: Robichaud A]]
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[[Category: Schindler R]]
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[[Category: Stange H]]

Current revision

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

PDB ID 3snl

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