3t8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor== | |
| + | <StructureSection load='3t8s' size='340' side='right'caption='[[3t8s]], [[Resolution|resolution]] 3.77Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3t8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.77Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8s OCA], [https://pdbe.org/3t8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8s RCSB], [https://www.ebi.ac.uk/pdbsum/3t8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Baek K]] | ||
| + | [[Category: Lin C]] | ||
| + | [[Category: Lu Z]] | ||
Current revision
Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor
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