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2oxj

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Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.

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Retrieved from "http://52.214.119.220/wiki/index.php/2oxj"

Categories: Large Structures | Gellman SH | Horne WS | Keck JL | Price JL

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-[[Image:2oxj.gif|left|200px]]<br /><applet load="2oxj" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2oxj, resolution 2.00&Aring;" />
-'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.'''<br />
-==Overview==
+==Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.==
-The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure.
+<StructureSection load='2oxj' size='340' side='right'caption='[[2oxj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2oxj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OXJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B3A:(3S)-3-AMINOBUTANOIC+ACID'>B3A</scene>, <scene name='pdbligand=B3D:3-AMINOPENTANEDIOIC+ACID'>B3D</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3K:(3S)-3,7-DIAMINOHEPTANOIC+ACID'>B3K</scene>, <scene name='pdbligand=B3S:(3R)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>B3S</scene>, <scene name='pdbligand=B3X:(3S)-3,5-DIAMINO-5-OXOPENTANOIC+ACID'>B3X</scene>, <scene name='pdbligand=B3Y:(3S)-3-AMINO-4-(4-HYDROXYPHENYL)BUTANOIC+ACID'>B3Y</scene>, <scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxj OCA], [https://pdbe.org/2oxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oxj RCSB], [https://www.ebi.ac.uk/pdbsum/2oxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oxj ProSAT]</span></td></tr>
+</table>
-==About this Structure==
+==See Also==
-OXJ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXJ OCA].
+*[[Gcn4 3D Structures|Gcn4 3D Structures]]
+*[[Gnc4 3D Structures|Gnc4 3D Structures]]
-==Reference==
+__TOC__
-Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
+</StructureSection>
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Gellman, S.H.]]
+[[Category: Gellman SH]]
-[[Category: Horne, W.S.]]
+[[Category: Horne WS]]
-[[Category: Keck, J.L.]]
+[[Category: Keck JL]]
-[[Category: Price, J.L.]]
+[[Category: Price JL]]
-[[Category: ACT]]
-[[Category: coiled coil]]
-[[Category: foldamer]]
-[[Category: helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:17:23 2008''

2oxj

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Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.

Structural highlights

See Also

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