2l1e

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[[Image:2l1e.jpg|left|200px]]
 
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==Mouse prion protein (121-231) containing the substitution F175A==
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The line below this paragraph, containing "STRUCTURE_2l1e", creates the "Structure Box" on the page.
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<StructureSection load='2l1e' size='340' side='right'caption='[[2l1e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1e OCA], [https://pdbe.org/2l1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1e RCSB], [https://www.ebi.ac.uk/pdbsum/2l1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1e ProSAT]</span></td></tr>
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{{STRUCTURE_2l1e| PDB=2l1e | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structures of prion proteins (PrPs) in the cellular form (PrP(C)) include a stacking interaction between the aromatic rings of the residues Y169 and F175, where F175 is conserved in all but two so far analyzed mammalian PrP sequences and where Y169 is strictly conserved. To investigate the structural role of F175, we characterized the variant mouse prion protein mPrP[F175A](121-231). The NMR solution structure represents a typical PrP(C)-fold, and it contains a 3(10)-helical beta2-alpha2 loop conformation, which is well defined because all amide group signals in this loop are observed at 20 degrees C. With this "rigid-loop PrP(C)" behavior, mPrP[F175A](121-231) differs from the previously studied mPrP[Y169A](121-231), which contains a type I beta-turn beta2-alpha2 loop structure. When compared to other rigid-loop variants of mPrP(121-231), mPrP[F175A](121-231) is unique in that the thermal unfolding temperature is lowered by 8 degrees C. These observations enable further refined dissection of the effects of different single-residue exchanges on the PrP(C) conformation and their implications for the PrP(C) physiological function.
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===Mouse prion protein (121-231) containing the substitution F175A===
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Prion Protein mPrP[F175A](121-231): Structure and Stability in Solution.,Christen B, Hornemann S, Damberger FF, Wuthrich K J Mol Biol. 2012 Nov 2;423(4):496-502. doi: 10.1016/j.jmb.2012.08.011. Epub 2012 , Aug 24. PMID:22922482<ref>PMID:22922482</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l1e" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2l1e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1E OCA].
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*[[Prion 3D structures|Prion 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Christen, B.]]
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[[Category: Christen B]]
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[[Category: Damberger, F F.]]
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[[Category: Damberger FF]]
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[[Category: Hornemann, S.]]
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[[Category: Hornemann S]]
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[[Category: Perez, D R.]]
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[[Category: Perez DR]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: Membrane protein]]
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[[Category: Mutation]]
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[[Category: Prion]]
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Current revision

Mouse prion protein (121-231) containing the substitution F175A

PDB ID 2l1e

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