3au8

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[[Image:3au8.jpg|left|200px]]
 
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==Crystal structure of the ternary complex of an isomerase==
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The line below this paragraph, containing "STRUCTURE_3au8", creates the "Structure Box" on the page.
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<StructureSection load='3au8' size='340' side='right'caption='[[3au8]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3au8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AU8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_3au8| PDB=3au8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3au8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3au8 OCA], [https://pdbe.org/3au8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3au8 RCSB], [https://www.ebi.ac.uk/pdbsum/3au8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3au8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DXR_PLAFX DXR_PLAFX] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).<ref>PMID:10477522</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human malaria parasite Plasmodium falciparum is responsible for the deaths of more than a million people each year. Fosmidomycin has been proven to be efficient in the treatment of P. falciparum malaria by inhibiting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an enzyme of the non-mevalonate pathway, which is absent in humans. However, the structural details of DXR inhibition by fosmidomycin in P. falciparum are unknown. Here, we report the crystal structures of fosmidomycin-bound complete quaternary complexes of PfDXR. Our study revealed that (i) an intrinsic flexibility of the PfDXR molecule accounts for an induced-fit movement to accommodate the bound inhibitor in the active site and (ii) a cis arrangement of the oxygen atoms of the hydroxamate group of the bound inhibitor is essential for tight binding of the inhibitor to the active site metal. We expect the present structures to be useful guides for the design of more effective antimalarial compounds.
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===Crystal structure of the ternary complex of an isomerase===
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Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum.,Umeda T, Tanaka N, Kusakabe Y, Nakanishi M, Kitade Y, Nakamura KT Sci Rep. 2011;1:9. doi: 10.1038/srep00009. Epub 2011 Jun 14. PMID:22355528<ref>PMID:22355528</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3au8" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3au8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU8 OCA].
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Kitade, Y.]]
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[[Category: Kitade Y]]
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[[Category: Kusakabe, Y.]]
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[[Category: Kusakabe Y]]
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[[Category: Nakamura, K T.]]
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[[Category: Nakamura KT]]
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[[Category: Nakanishi, M.]]
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[[Category: Nakanishi M]]
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[[Category: Tanaka, N.]]
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[[Category: Tanaka N]]
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[[Category: Umeda, T.]]
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[[Category: Umeda T]]
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[[Category: Isomerase]]
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[[Category: Nadph binding]]
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Current revision

Crystal structure of the ternary complex of an isomerase

PDB ID 3au8

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