3rbt

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[[Image:3rbt.jpg|left|200px]]
 
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==Crystal structure of glutathione S-transferase Omega 3 from the silkworm Bombyx mori==
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The line below this paragraph, containing "STRUCTURE_3rbt", creates the "Structure Box" on the page.
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<StructureSection load='3rbt' size='340' side='right'caption='[[3rbt]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rbt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RBT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3rbt| PDB=3rbt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbt OCA], [https://pdbe.org/3rbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rbt RCSB], [https://www.ebi.ac.uk/pdbsum/3rbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rbt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q1HPV9_BOMMO Q1HPV9_BOMMO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutathione transferases (GSTs) are ubiquitous detoxification enzymes that conjugate hydrophobic xenobiotics with reduced glutathione. The silkworm Bombyx mori encodes four isoforms of GST Omega (GSTO), featured with a catalytic cysteine, except that bmGSTO3-3 has an asparagine substitution of this catalytic residue. Here, we determined the 2.20-A crystal structure of bmGSTO3-3, which shares a typical GST overall structure. However, the extended C-terminal segment that exists in all the four bmGSTOs occupies the G-site of bmGSTO3-3 and makes it unworkable, as shown by the activity assays. Upon mutation of Asn29 to Cys and truncation of the C-terminal segment, the in vitro GST activity of bmGSTO3-3 could be restored. These findings provided structural insights into the activity regulation of GSTOs.
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===Crystal structure of glutathione S-transferase Omega 3 from the silkworm Bombyx mori===
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Structure-guided activity restoration of the silkworm glutathione transferase Omega GSTO3-3.,Chen BY, Ma XX, Guo PC, Tan X, Li WF, Yang JP, Zhang NN, Chen Y, Xia Q, Zhou CZ J Mol Biol. 2011 Sep 16;412(2):204-11. Epub 2011 Jul 22. PMID:21816159<ref>PMID:21816159</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rbt" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3rbt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBT OCA].
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bombyx mori]]
[[Category: Bombyx mori]]
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[[Category: Glutathione transferase]]
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[[Category: Large Structures]]
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[[Category: Chen, B Y.]]
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[[Category: Chen B-Y]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Li, W F.]]
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[[Category: Li W-F]]
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[[Category: Ma, X X.]]
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[[Category: Ma X-X]]
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[[Category: Tan, X.]]
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[[Category: Tan X]]
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[[Category: Xia, Q.]]
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[[Category: Xia Q]]
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[[Category: Yang, J P.]]
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[[Category: Yang J-P]]
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[[Category: Zhang, N N.]]
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[[Category: Zhang N-N]]
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[[Category: Zhou, C Z.]]
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[[Category: Zhou C-Z]]
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[[Category: Glutathione s-transferase omega3]]
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[[Category: Transferase]]
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Current revision

Crystal structure of glutathione S-transferase Omega 3 from the silkworm Bombyx mori

PDB ID 3rbt

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