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3rgf
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| - | [[Image:3rgf.jpg|left|200px]] | ||
| - | < | + | ==Crystal Structure of human CDK8/CycC== |
| - | + | <StructureSection load='3rgf' size='340' side='right'caption='[[3rgf]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAX:4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE'>BAX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgf OCA], [https://pdbe.org/3rgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgf RCSB], [https://www.ebi.ac.uk/pdbsum/3rgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgf ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDK8_HUMAN CDK8_HUMAN] Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.<ref>PMID:10993082</ref> <ref>PMID:15546612</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Cyclin 3D structures|Cyclin 3D structures]] | |
| - | + | *[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]] | |
| - | == | + | == References == |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blaesse | + | [[Category: Large Structures]] |
| - | [[Category: Boettcher | + | [[Category: Blaesse M]] |
| - | [[Category: Huber | + | [[Category: Boettcher J]] |
| - | [[Category: Maskos | + | [[Category: Huber R]] |
| - | [[Category: Schneider | + | [[Category: Maskos K]] |
| - | + | [[Category: Schneider EV]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of human CDK8/CycC
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