3t42
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human aldose reductase in complex with a nitrile-containing IDD inhibitor== | |
| + | <StructureSection load='3t42' size='340' side='right'caption='[[3t42]], [[Resolution|resolution]] 1.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3t42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T42 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3T4:{5-CHLORO-2-[(4-CYANO-3-NITROBENZYL)CARBAMOYL]PHENOXY}ACETIC+ACID'>3T4</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t42 OCA], [https://pdbe.org/3t42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t42 RCSB], [https://www.ebi.ac.uk/pdbsum/3t42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t42 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | ||
| - | + | ==See Also== | |
| - | + | *[[Aldose reductase 3D structures|Aldose reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boxer SG]] | ||
| + | [[Category: Cohen AE]] | ||
| + | [[Category: Xu L]] | ||
Current revision
Human aldose reductase in complex with a nitrile-containing IDD inhibitor
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