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3tcx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation== | |
| + | <StructureSection load='3tcx' size='340' side='right'caption='[[3tcx]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tcx]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TCX FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ICAM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ITGAL, CD11A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tcx OCA], [https://pdbe.org/3tcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tcx RCSB], [https://www.ebi.ac.uk/pdbsum/3tcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tcx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN]] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref> [[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. | ||
| - | + | ==See Also== | |
| - | + | *[[Integrin 3D structures|Integrin 3D structures]] | |
| - | + | *[[Intercellular adhesion molecule|Intercellular adhesion molecule]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boonyaleepun, V]] | ||
| + | [[Category: Gu, X]] | ||
| + | [[Category: Jin, M M]] | ||
| + | [[Category: Kang, S]] | ||
| + | [[Category: Kim, C U]] | ||
| + | [[Category: Mao, Y]] | ||
| + | [[Category: Owens, R M]] | ||
| + | [[Category: Rijn, S J.van]] | ||
| + | [[Category: Springer, T A]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Immunoglobulin-like fold]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Rossmann fold]] | ||
Current revision
Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation
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Categories: Human | Large Structures | Boonyaleepun, V | Gu, X | Jin, M M | Kang, S | Kim, C U | Mao, Y | Owens, R M | Rijn, S J.van | Springer, T A | Cell adhesion | Immunoglobulin-like fold | Membrane | Rossmann fold
