3tda

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'''Unreleased structure'''
 
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The entry 3tda is ON HOLD
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==Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6==
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<StructureSection load='3tda' size='340' side='right'caption='[[3tda]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TDA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PN0:PRINOMASTAT'>PN0</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tda OCA], [https://pdbe.org/3tda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tda RCSB], [https://www.ebi.ac.uk/pdbsum/3tda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tda ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
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Authors: Wang, A, Stout, C.D., Johnson, E.F.
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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Description: Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Johnson EF]]
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[[Category: Stout CD]]
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[[Category: Wang A]]

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Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6

PDB ID 3tda

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