3ay0

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[[Image:3ay0.jpg|left|200px]]
 
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==Crystal structure of Methanocaldococcus jannaschii Trm5 in complex with adenosine==
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The line below this paragraph, containing "STRUCTURE_3ay0", creates the "Structure Box" on the page.
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<StructureSection load='3ay0' size='340' side='right'caption='[[3ay0]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ay0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AY0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ay0| PDB=3ay0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ay0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ay0 OCA], [https://pdbe.org/3ay0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ay0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ay0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ay0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRM5B_METJA TRM5B_METJA] Specifically methylates the N1 position of guanosine-37 in various tRNAs.<ref>PMID:15165845</ref> <ref>PMID:16768442</ref> <ref>PMID:20980671</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial TrmD and eukaryotic-archaeal Trm5 form a pair of analogous tRNA methyltransferase that catalyze methyl transfer from S-adenosyl methionine (AdoMet) to N(1) of G37, using catalytic motifs that share no sequence or structural homology. Here we show that natural and synthetic analogs of AdoMet are unable to distinguish TrmD from Trm5. Instead, fragments of AdoMet, adenosine and methionine, are selectively inhibitory of TrmD rather than Trm5. Detailed structural information of the two enzymes in complex with adenosine reveals how Trm5 escapes targeting by adopting an altered structure, whereas TrmD is trapped by targeting due to its rigid structure that stably accommodates the fragment. Free energy analysis exposes energetic disparities between the two enzymes in how they approach the binding of AdoMet versus fragments and provides insights into the design of inhibitors selective for TrmD.
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===Crystal structure of Methanocaldococcus jannaschii Trm5 in complex with adenosine===
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Differentiating analogous tRNA methyltransferases by fragments of the methyl donor.,Lahoud G, Goto-Ito S, Yoshida K, Ito T, Yokoyama S, Hou YM RNA. 2011 Jul;17(7):1236-46. Epub 2011 May 20. PMID:21602303<ref>PMID:21602303</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ay0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21602303}}, adds the Publication Abstract to the page
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*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21602303 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21602303}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3ay0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AY0 OCA].
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==Reference==
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<ref group="xtra">PMID:021602303</ref><references group="xtra"/>
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Goto-Ito, S.]]
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[[Category: Goto-Ito S]]
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[[Category: Hou, Y M.]]
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[[Category: Hou YM]]
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[[Category: Ito, T.]]
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[[Category: Ito T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Adomet binding]]
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[[Category: Methyltransferase]]
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[[Category: Rossmann fold]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Methanocaldococcus jannaschii Trm5 in complex with adenosine

PDB ID 3ay0

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