3oob

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[[Image:3oob.jpg|left|200px]]
 
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==Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate==
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The line below this paragraph, containing "STRUCTURE_3oob", creates the "Structure Box" on the page.
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<StructureSection load='3oob' size='340' side='right'caption='[[3oob]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3oob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OOB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDH:(2R,3R)-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-2H-CHROMEN-3-YL+3,4,5-TRIHYDROXYBENZOATE'>KDH</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3oob| PDB=3oob | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oob OCA], [https://pdbe.org/3oob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oob RCSB], [https://www.ebi.ac.uk/pdbsum/3oob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oob ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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===Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate===
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==See Also==
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21750208}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21750208 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21750208}}
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==About this Structure==
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[[3oob]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OOB OCA].
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==Reference==
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<ref group="xtra">PMID:021750208</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bode, A M.]]
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[[Category: Bode AM]]
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[[Category: Dong, Z.]]
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[[Category: Dong Z]]
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[[Category: Jung, S K.]]
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[[Category: Jung SK]]
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[[Category: Kim, D J.]]
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[[Category: Kim D-J]]
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[[Category: Shim, J H.]]
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[[Category: Shim J-H]]
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[[Category: Urusova, D V.]]
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[[Category: Urusova DV]]
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[[Category: Zykova, T A.]]
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[[Category: Zykova TA]]
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[[Category: Isomerase]]
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[[Category: Phosphorylation-dependent cis/trans isomerase]]
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[[Category: Proteins with pser/pthr-pro motif]]
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[[Category: Ww domain-like peptidyl prolyl isomerase]]
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Current revision

Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate

PDB ID 3oob

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OCA

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