2xh6

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[[Image:2xh6.png|left|200px]]
 
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==Clostridium perfringens enterotoxin==
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The line below this paragraph, containing "STRUCTURE_2xh6", creates the "Structure Box" on the page.
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<StructureSection load='2xh6' size='340' side='right'caption='[[2xh6]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xh6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XH6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene></td></tr>
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{{STRUCTURE_2xh6| PDB=2xh6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xh6 OCA], [https://pdbe.org/2xh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xh6 RCSB], [https://www.ebi.ac.uk/pdbsum/2xh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xh6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELTB_CLOPF ELTB_CLOPF] This enterotoxin is responsible for many cases of a mild type of food poisoning.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated diarrhea. Upon its release from C. perfringens spores, CPE binds to its receptor, claudin, at the tight junctions between the epithelial cells of the gut wall and subsequently forms pores in the cell membranes. A number of different complexes between CPE and claudin have been observed, and the process of pore formation has not been fully elucidated. We have determined the three-dimensional structure of the soluble form of CPE in two crystal forms by X-ray crystallography, to a resolution of 2.7 and 4.0 A, respectively, and found that the N-terminal domain shows structural homology with the aerolysin-like beta-pore-forming family of proteins. We show that CPE forms a trimer in both crystal forms and that this trimer is likely to be biologically relevant but is not the active pore form. We use these data to discuss models of pore formation.
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===CLOSTRIDIUM PERFRINGENS ENTEROTOXIN===
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Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins.,Briggs DC, Naylor CE, Smedley JG 3rd, Lukoyanova N, Robertson S, Moss DS, McClane BA, Basak AK J Mol Biol. 2011 Oct 14;413(1):138-49. Epub 2011 Aug 3. PMID:21839091<ref>PMID:21839091</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20606275}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2xh6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20606275 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20606275}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2xh6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH6 OCA].
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==Reference==
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<ref group="xtra">PMID:020606275</ref><references group="xtra"/>
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[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
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[[Category: Basak, A K.]]
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[[Category: Large Structures]]
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[[Category: Briggs, D C.]]
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[[Category: Basak AK]]
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[[Category: III, J G.Smedley.]]
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[[Category: Briggs DC]]
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[[Category: Mcclane, B A.]]
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[[Category: MCClane BA]]
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[[Category: Naylor, C E.]]
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[[Category: Naylor CE]]
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[[Category: Antibiotic-associated diarrhoea]]
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[[Category: Smedley III JG]]
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[[Category: Food poisoning]]
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[[Category: Toxin]]
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Current revision

Clostridium perfringens enterotoxin

PDB ID 2xh6

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