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Hemolysin
From Proteopedia
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| - | + | <StructureSection load='7ahl' size='350' side='right' caption='α-hemolysin heptamer (PDB code [[7ahl]]).' scene=''> | |
| + | == Function == | ||
| + | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. '''α-hemolysin''' from the bacterium ''Clostridium'' are called '''alpha-toxin'''. They are zinc metalloenzymes which bind to the membrane in the presence of calcium. It acts as a phospholipase C. | ||
| - | + | See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]]. | |
| + | See details of hemolysin E in [[Molecular Playground/ClyA]]. | ||
| - | + | For toxins in Proteopdia see [[Toxins]]. | |
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| + | == Relevance == | ||
| + | HL acts as a virulence factor in the pathogenesis of invasive infections<ref>PMID:12564994</ref>. | ||
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| + | ==3D Printed Physical Model of Hemolysin== | ||
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| + | Shown below is a 3D printed physical model of Hemolysin. The model is shown in alpha carbon backbone format with each chain colored uniquely. | ||
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| + | [[Image:hemolysin1_centerForBioMolecularModeling.jpg|550px]] | ||
| + | [[Image:hemolysin2_centerForBioMolecularModeling.jpg|550px]] | ||
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| + | ====The MSOE Center for BioMolecular Modeling==== | ||
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| + | [[Image:CbmUniversityLogo.jpg | left | 150px]] | ||
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| + | The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery]. | ||
== 3D Structures of hemolysin == | == 3D Structures of hemolysin == | ||
| + | [[Hemolysin 3D structures]] | ||
| + | </StructureSection> | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774
- ↑ Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec;10(12):575-80. PMID:12564994
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