2c95

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[[Image:2c95.png|left|200px]]
 
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==Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate==
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The line below this paragraph, containing "STRUCTURE_2c95", creates the "Structure Box" on the page.
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<StructureSection load='2c95' size='340' side='right'caption='[[2c95]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2c95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C95 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B4P:BIS(ADENOSINE)-5-TETRAPHOSPHATE'>B4P</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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{{STRUCTURE_2c95| PDB=2c95 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c95 OCA], [https://pdbe.org/2c95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c95 RCSB], [https://www.ebi.ac.uk/pdbsum/2c95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c95 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:[https://omim.org/entry/612631 612631].<ref>PMID:2542324</ref> <ref>PMID:9432020</ref> <ref>PMID:12649162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/2c95_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c95 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF ADENYLATE KINASE 1 IN COMPLEX WITH P1,P4-DI (ADENOSINE)TETRAPHOSPHATE===
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==See Also==
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2c95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C95 OCA].
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__TOC__
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[[Category: Adenylate kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G.]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F Von.]]
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[[Category: Bunkoczi G]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Jansson, A.]]
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[[Category: Jansson A]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Longman, E.]]
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[[Category: Longman E]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Ap4a]]
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[[Category: Von Delft F]]
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[[Category: Nucleotide kinase]]
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[[Category: Transferase]]
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[[Category: Transferase atp-binding]]
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Current revision

Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate

PDB ID 2c95

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