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3ps5

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[[Image:3ps5.png|left|200px]]
 
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==Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1==
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The line below this paragraph, containing "STRUCTURE_3ps5", creates the "Structure Box" on the page.
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<StructureSection load='3ps5' size='340' side='right'caption='[[3ps5]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ps5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PS5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ps5| PDB=3ps5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ps5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ps5 OCA], [https://pdbe.org/3ps5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ps5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ps5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ps5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SHP-1 belongs to the family of non-receptor protein tyrosine phosphatases (PTPs) and generally acts as a negative regulator in a variety of cellular signaling pathways. Previously the crystal structures of the tail-truncated SHP-1 and SHP-2 revealed an autoinhibitory conformation. To understand the regulatory mechanism of SHP-1, we have determined the crystal structure of the full length SHP-1 at 3.1 A. Although the tail was disordered in current structure, the huge conformational rearrangement of the N-SH2 domain and the incorporation of sulfate ions into the ligand-binding site of each domain indicate that the SHP-1 is in the open conformation. The N-SH2 domain in current structure is shifted away from the active site of the PTP domain to the other side of the C-SH2 domain, resulting in exposure of the active site. Meanwhile, the C-SH2 domain is twisted anticlockwise by about 110 degrees . In addition, a set of new interactions between two SH2 domains and between the N-SH2 and the catalytic domains is identified, which could be responsible for the stabilization of SHP-1 in the open conformation. Based on the structural comparison, a model for the activation of SHP-1 is proposed. (c) 2011 Wiley-Liss, Inc.
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===Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1===
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Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.,Wang W, Liu L, Song X, Mo Y, Komma C, Bellamy HD, Zhao ZJ, Zhou GW J Cell Biochem. 2011 Apr 4. doi: 10.1002/jcb.23125. PMID:21465528<ref>PMID:21465528</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ps5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21465528 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21465528}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3ps5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PS5 OCA].
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==Reference==
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<ref group="xtra">PMID:021465528</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Bellamy, H D.]]
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[[Category: Bellamy HD]]
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[[Category: Komma, C.]]
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[[Category: Komma C]]
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[[Category: Liu, L.]]
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[[Category: Liu L]]
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[[Category: Mo, Y.]]
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[[Category: Mo Y]]
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[[Category: Song, X.]]
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[[Category: Song X]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Zhao, Z J.]]
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[[Category: Zhao ZJ]]
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[[Category: Zhou, G W.]]
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[[Category: Zhou GW]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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[[Category: Ptp]]
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[[Category: Sh2]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1

PDB ID 3ps5

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