3r84

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (02:20, 21 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3r84.png|left|200px]]
 
-
<!--
+
==Structure of the Mediator head subcomplex Med11/22==
-
The line below this paragraph, containing "STRUCTURE_3r84", creates the "Structure Box" on the page.
+
<StructureSection load='3r84' size='340' side='right'caption='[[3r84]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3r84]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R84 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_3r84| PDB=3r84 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r84 OCA], [https://pdbe.org/3r84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r84 RCSB], [https://www.ebi.ac.uk/pdbsum/3r84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r84 ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Mediator is a multiprotein co-activator of RNA polymerase (Pol) II transcription. Mediator contains a conserved core that comprises the 'head' and 'middle' modules. We present here a structure-function analysis of the essential Med11/22 heterodimer, a part of the head module. Med11/22 forms a conserved four-helix bundle domain with C-terminal extensions, which bind the central head subunit Med17. A highly conserved patch on the bundle surface is required for stable transcription pre-initiation complex formation on a Pol II promoter in vitro and in vivo and may recruit the general transcription factor TFIIH. The bundle domain fold is also present in the Mediator middle module subcomplex Med7/21 and is predicted in the Mediator heterodimers Med2/3, Med4/9, Med10/14 and Med28/30. The bundle domain thus represents a common building block that has been multiplied and functionally diversified during Mediator evolution in eukaryotes.
-
===Structure of the Mediator head subcomplex Med11/22===
+
Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.,Seizl M, Lariviere L, Pfaffeneder T, Wenzeck L, Cramer P Nucleic Acids Res. 2011 Apr 15. PMID:21498544<ref>PMID:21498544</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3r84" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_21498544}}, adds the Publication Abstract to the page
+
*[[Mediator|Mediator]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21498544 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21498544}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[3r84]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R84 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021498544</ref><references group="xtra"/>
+
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Cramer, P.]]
+
[[Category: Cramer P]]
-
[[Category: Lariviere, L.]]
+
[[Category: Lariviere L]]
-
[[Category: Pfaffenender, T.]]
+
[[Category: Pfaffenender T]]
-
[[Category: Seizl, M.]]
+
[[Category: Seizl M]]
-
[[Category: Wenzeck, L.]]
+
[[Category: Wenzeck L]]
-
[[Category: Four-helix bundle]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Transcription]]
+

Current revision

Structure of the Mediator head subcomplex Med11/22

PDB ID 3r84

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3r84"
Personal tools