2ce9

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[[Image:2ce9.png|left|200px]]
 
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==A WRPW peptide bound to the Groucho-TLE WD40 domain.==
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The line below this paragraph, containing "STRUCTURE_2ce9", creates the "Structure Box" on the page.
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<StructureSection load='2ce9' size='340' side='right'caption='[[2ce9]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ce9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CE9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ce9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ce9 OCA], [https://pdbe.org/2ce9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ce9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ce9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ce9 ProSAT]</span></td></tr>
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{{STRUCTURE_2ce9| PDB=2ce9 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/2ce9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ce9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Groucho (Gro)/TLE/Grg family of corepressors operates in many signaling pathways (including Notch and Wnt). Gro/TLE proteins recognize a wide range of transcriptional repressors by binding to divergent short peptide sequences, including a C-terminal WRPW/Y motif (Hairy/Hes/Runx) and internal eh1 motifs (FxIxxIL; Engrailed/Goosecoid/Pax/Nkx). Here, we identify several missense mutations in Drosophila Gro, which demonstrate peptide binding to the central pore of the WD (WD40) beta propeller domain in vitro and in vivo. We define these interactions at the molecular level with crystal structures of the WD domain of human TLE1 bound to either WRPW or eh1 peptides. The two distinct peptide motifs adopt markedly different bound conformations but occupy overlapping sites across the central pore of the beta propeller. Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo.
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===A WRPW PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN.===
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Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor.,Jennings BH, Pickles LM, Wainwright SM, Roe SM, Pearl LH, Ish-Horowicz D Mol Cell. 2006 Jun 9;22(5):645-55. PMID:16762837<ref>PMID:16762837</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2ce9" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16762837 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16762837}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2ce9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CE9 OCA].
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==Reference==
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<ref group="xtra">PMID:016762837</ref><ref group="xtra">PMID:012057191</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pearl, L H.]]
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[[Category: Large Structures]]
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[[Category: Pickles, L M.]]
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[[Category: Pearl LH]]
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[[Category: Roe, S M.]]
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[[Category: Pickles LM]]
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[[Category: Nuclear protein]]
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[[Category: Roe SM]]
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[[Category: Phosphorylation]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcriptional co-repressor]]
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[[Category: Wd repeat]]
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[[Category: Wd40 domain]]
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[[Category: Wnt signaling pathway]]
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Current revision

A WRPW peptide bound to the Groucho-TLE WD40 domain.

PDB ID 2ce9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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