2w1z

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[[Image:2w1z.png|left|200px]]
 
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==ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.==
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The line below this paragraph, containing "STRUCTURE_2w1z", creates the "Structure Box" on the page.
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<StructureSection load='2w1z' size='340' side='right'caption='[[2w1z]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2w1z| PDB=2w1z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1z OCA], [https://pdbe.org/2w1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1z RCSB], [https://www.ebi.ac.uk/pdbsum/2w1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q27007_TOXGO Q27007_TOXGO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2.
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===ROP2 FROM TOXOPLASMA GONDII: A VIRULENCE FACTOR WITH A PROTEIN-KINASE FOLD AND NO ENZYMATIC ACTIVITY.===
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ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.,Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF Structure. 2009 Jan 14;17(1):139-46. PMID:19141290<ref>PMID:19141290</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_019141290}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2w1z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 019141290 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_019141290}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2w1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA].
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[[Category: Toxoplasma gondii RH]]
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[[Category: Arold ST]]
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==Reference==
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[[Category: Bessin Y]]
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<ref group="xtra">PMID:019141290</ref><references group="xtra"/>
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[[Category: Dubremetz J-F]]
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[[Category: Toxoplasma gondii]]
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[[Category: Gelin M]]
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[[Category: Arold, S.]]
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[[Category: Labesse G]]
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[[Category: Bessin, Y.]]
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[[Category: Lebrun M]]
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[[Category: Dubremetz, J F.]]
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[[Category: Gelin, M.]]
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[[Category: Labesse, G.]]
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[[Category: Lebrun, M.]]
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[[Category: Inactivity]]
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[[Category: Membrane-attachment]]
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[[Category: Protein-kinase]]
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[[Category: Transferase]]
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Current revision

ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.

PDB ID 2w1z

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