2vy9

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[[Image:2vy9.png|left|200px]]
 
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==Molecular architecture of the stressosome, a signal integration and transduction hub==
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The line below this paragraph, containing "STRUCTURE_2vy9", creates the "Structure Box" on the page.
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<StructureSection load='2vy9' size='340' side='right'caption='[[2vy9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vy9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VY9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2vy9| PDB=2vy9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vy9 OCA], [https://pdbe.org/2vy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vy9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q2RIF5_MOOTA Q2RIF5_MOOTA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vy9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vy9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.
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===MOLECULAR ARCHITECTURE OF THE STRESSOSOME, A SIGNAL INTEGRATION AND TRANSDUCTION HUB===
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Molecular architecture of the "stressosome," a signal integration and transduction hub.,Marles-Wright J, Grant T, Delumeau O, van Duinen G, Firbank SJ, Lewis PJ, Murray JW, Newman JA, Quin MB, Race PR, Rohou A, Tichelaar W, van Heel M, Lewis RJ Science. 2008 Oct 3;322(5898):92-6. PMID:18832644<ref>PMID:18832644</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vy9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18832644}}, adds the Publication Abstract to the page
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*[[Anti-sigma factor antagonist 3D structures|Anti-sigma factor antagonist 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18832644 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18832644}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2vy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VY9 OCA].
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==Reference==
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<ref group="xtra">PMID:018832644</ref><references group="xtra"/>
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[[Category: Moorella thermoacetica]]
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[[Category: Delumeau, O.]]
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[[Category: Duinen, G Van.]]
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[[Category: Firbank, S J.]]
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[[Category: Grant, T.]]
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[[Category: Heel, M Van.]]
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[[Category: Lewis, P J.]]
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[[Category: Lewis, R J.]]
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[[Category: Marles-Wright, J.]]
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[[Category: Murray, J W.]]
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[[Category: Newman, J A.]]
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[[Category: Quin, M B.]]
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[[Category: Race, P R.]]
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[[Category: Rohou, A.]]
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[[Category: Tichelaar, W.]]
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[[Category: Bacillus subtili]]
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[[Category: Gene regulation]]
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[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
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[[Category: Rsb]]
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[[Category: Delumeau O]]
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[[Category: Stas domain]]
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[[Category: Firbank SJ]]
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[[Category: Stressosome]]
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[[Category: Grant T]]
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[[Category: Lewis PJ]]
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[[Category: Lewis RJ]]
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[[Category: Marles-Wright J]]
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[[Category: Murray JW]]
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[[Category: Newman JA]]
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[[Category: Quin MB]]
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[[Category: Race PR]]
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[[Category: Rohou A]]
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[[Category: Tichelaar W]]
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[[Category: Van Duinen G]]
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[[Category: Van Heel M]]

Current revision

Molecular architecture of the stressosome, a signal integration and transduction hub

PDB ID 2vy9

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